DNA origami nanostructures for controlled therapeutic drug delivery

DNA nanostructures are emerging as a versatile platform for controlled drug delivery result of recent progress in production yield and strategies to obtain prolonged stability biological environments. The construction from this unique biomaterial provides unparalleled control over structural functional parameters. Recent applications origami-based nanocarriers therapeutic preclinical phases highlight them promising alternatives conventional nanomaterials, they benefit the inherent favorable properties including biocompatibility precise spatial addressability. By incorporating targeting aptamers responsive into nanocarrier design, more selective successfully prepared. On other hand, current systems remain poorly understood terms biodistribution, final fate, release. As such, advances needed translate material its full potential applications. • Advances origami allow biomedical Drug can high programmability DNA. Targeting release enhance selectivity. biodistribution need better understanding. Surprisingly, nanostructure costs will not hinder translation.